ERA - Taiwan

技術概論

ERA
Indications
Benefits

什麼是 ERA檢測?

由Igenomix 開發並取得唯一專利權的子宮內膜容受性檢測（ERA）是專為子宮內膜容受性所設計的檢測。

這項技術是利用NGS分析248個與子宮內膜容受性狀態有關的基因表現。

已有多項研究證實ERA 檢測在偵測與容受性有關的基因表現圖譜，具有高靈敏度和特異性。利用ERA檢測，可在患者進行人工生殖技前，檢測其個人著床窗期。

進行ERA時，Igenomix 特有的AI演算法會先分析取自子宮內膜組織樣本的RNA，依RNA表現圖譜，再將其分類為容受性或非容受性。

若子宮內膜結果是非容受性，ERA檢測能夠找出專屬每一位患者的個人著床窗期。

子宮內膜的重要性

檢測流程

Who should use ERA test?

Women who have experienced implantation failure with morphologically good quality embryos.
Women with a morphologically normal uterus and normal endometrial thickness (≥ 6 mm), where the uterus and endometrium are unlikely to be the problem.

When is a second biopsy needed?

90 % of cases don’t need a second biopsy. The second biopsy is only required under two circumstances:

Patients with a “Pre-receptive 2 days” result.
Patients with a “Post-receptive” result.

Test limitations

There is a risk (<5%) to get a non-informative result, in which the biopsy procedure has failed to obtain a sufficient quantity and/or quality of tissue to be able to make a diagnosis. If this should occur a new biopsy will be required.

The aim of this test Is to provide physicians with an objective molecular diagnosis of the patient´s endometrial timing of receptivity. Depending on the results of this test, the physician may use it as a guide for personalized embryo transfer.

Pregnancy is not guaranteed, even with a receptive result. Poor embryo quality, genetic abnormalities, or previous pathologies can also reduce the likelihood of becoming pregnant.

The ERA® does not test for any other endometrial pathology and does not asses or provide a prediction for the health of a subsequent pregnancy.

Why use ERA test?

ERA is backed by 33 publications; 29 from Igenomix and 4 external publications.
Proprietary algorithm based on machine learning that minimizes the need for second biopsy (90% of cases).
Allows clinicians to identify transition phases with 12 hours shifts.
Randomized clinical trial (NCT01954758) RCT proves cumulative live birth rate increases +16 points VS classic frozen blastocyst transfer in first appointment patients:

文件與資源

ERA 的技術文件

The development of the ERA diagnostic tool was published in the paper by Díaz-Gimeno et al, 2011 (Fertil Steril. 2013 Feb; 99(2):508-17).

ERA´s effectiveness and consistency were demonstrated in the paper by Díaz-Gimeno et al, 2013 (Fertil Steril. 2013 Feb; 99 (2): 508-17).

ERA clinical applicability to patients with implantations failure was demonstrated in a publication by Ruiz-Alonso et al, 2013 and 2014.

What a difference two days make: “personalized” embryo transfer (pET) paradigm: a case report and pilot study Ruiz-Alonso M. et al, 2014. (Hum Reprod. 2014 Jun;29(6):1244-7)

A randomized study is currently in progress to assess its applicability to patients without any prior assisted reproduction treatment (ClinicalTrials.gov Identifier: NCT01954758).

The role of the endometrial receptivity array (ERA) in patients who have failed euploid embryo transfers. Tan J, Kan A, Hitkari J, Taylor B, Tallon N, Warraich G, Yuzpe A, Nakhuda G. J Assist Reprod Genet. 2018 Jan 11. doi: 10.1007/s10815-017-1112-2. [Epub ahead of print]

Combinatorial use of Endometrial Receptivity Array (ERA) and PGT-A can improve the clinical outcome in cases with previous ART failures. N. Findikli, M. Gultomruk, K. Boynukalin, M. Kavrut, E. Oral, M. Bahceci. ESHRE Oral communication.

Pregnancy outcomes in patients undergoing embryo transfer in cycle following endometrial receptivity assay. M. Pasternak, G. Schattman, Z. Rosenwaks. ASRM Poster.

The implantation rate of Japanese infertile patients with repeated implantation failure can be improved by endometrial receptivity array (ERA) test: A randomized controlled trial. S. Taguchi, M. Funabiki, T. Hayashi, Y. Tada, Y. Iwaki, M. Karita, T. Ota, K. Maeda, T. Matsubara, P. Zada, N. Sugiyama, Y. Nakamura. ASRM Oral communication.

Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two-centers study. Hashimoto T, Koizumi M, Doshida M, Toya M, Sagara E, Oka N, Nakajo Y, Aono N, Igarashi H, Kyono K. Reprod Med Biol. 2017 Jun 27;16(3):290-296. doi: 10.1002/rmb2.12041. eCollection 2017 Jul. PMID:29259480

Assessment of endometrial receptivity by endometrial receptivity array (ERA) in patients with adenomyosis and previous implantation failure in IVF. Kaur S, Mahajan N, Rani K, Naidu P, Kaur J. ESHRE Poster.

Mode of progesterone administration and its effects on endometrial receptivity in programmed frozen embryo transfer cycles. Rosen A, Huang A, Billb Y. PCRS Poster.

Endometrial Receptivity and pregnancy rates are higher after 7 days of progesterone in medicated FET cycles. A.M. Propst, L. Hansard, K. Silverberg, M. Hegtvedt, N.Z. Burger, T.C. Vaughn. ASRM Poster.

Endometrial receptivity array: Clinical application. Mahajan N. J Hum Reprod Sci. 2015 Jul-Sep;8(3):121-9. doi: 10.4103/0974-1208.165153. Review. PMID:26538853.

Live birth after embryo transfer in an unresponsive thin endometrium. F. Cruz, J. Bellver. Gynecol Endocrinol. 2014 Jul;30(7):481-4. doi: 10.3109/09513590.2014.900747. Epub 2014 Mar 20.

Mode of progesterone administration and its effects on endometrial receptivity in programmed frozen embryo transfer cycles. Rosen A, Huang A, Billb Y. PCRS Poster.

If you´re a little lost with this technical information...

Can we help you?

I’m not a health specialist

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

Learn more about Igenomix

其他您可能感興趣的檢測

EndomeTRIO

子宮內膜的全方位檢視

更多資訊

EMMA

評估子宮內膜的菌相

更多資訊

ALICE

檢測引起慢性子宮內膜炎的細菌

更多資訊

Igenomix 媒體報導

IGENOMIX與以上新聞媒體或出版社皆無關係。新聞報導並不代表對IGENOMIX或其服務與產品的支持。

強大的臨床研究結果

33 篇論文的支持

30% 的病患
擁有非標準化的著床窗期

已有超過8萬名病患受測

感興趣嗎?

什麼是 ERA檢測?

子宮內膜的重要性

檢測流程

Who should use ERA test?

When is a second biopsy needed?

Test limitations

Why use ERA test?

Technical Sheets

Brochure

相關文獻研究：

Can we help you?

Igenomix and fertility

Learn about genetics

NEW COURSES AVAILABLE:

Non Invasive PGS, Maria Vera

EndomeTRIO

EMMA

ALICE

ERA® 子宮內膜容受性檢測

透過個人化著床窗期植入胚胎

強大的臨床研究結果

33 篇論文的支持

30% 的病患 擁有非標準化的著床窗期

已有超過8萬名病患受測

感興趣嗎?

什麼是 ERA檢測?

子宮內膜的重要性

檢測流程

Who should use ERA test?

When is a second biopsy needed?

Test limitations

Why use ERA test?

Technical Sheets

Brochure

相關文獻研究：

Can we help you?

Igenomix and fertility

Learn about genetics

NEW COURSES AVAILABLE:

Non Invasive PGS, Maria Vera

其他您可能感興趣的檢測

EndomeTRIO

EMMA

ALICE

Igenomix 媒體報導

30% 的病患
擁有非標準化的著床窗期